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. Author manuscript; available in PMC: 2011 Mar 2.
Published in final edited form as: DNA Repair (Amst). 2010 Jan 22;9(3):202–209. doi: 10.1016/j.dnarep.2009.12.009

Figure 3.

Figure 3

Remodeling of stalled replication forks during replisome loading by the PriC pathway. The preferred DNA structure (i) for the PriC pathway is likely formed when the replisome encounters a leading-strand template blockage and the leading- and lagging-strand polymerases of the replicase uncouple. This results in a gap in the nascent leading strand at the stalled fork with the 5′ of the nascent lagging strand being either right at or close to the fork junction. Displacement of the nascent lagging-strand to allow DnaB loading to the lagging-strand template is most likely accomplished by PriC directing Rep to the proper DNA strand (ii).