Table 2. Variable parameters for seven unvaccinated animals infected with SIVmac251.
First row: Animal p88 from Ref. (Kuroda et al., 1999). Second to seventh row: Six control animals from vaccination trials (Letvin et al., 2006). Parameters are defined in Figures 2 to 4 and Table 1. Dynamic plots are shown in Figures 5 and 6. In addition to the parameter values shown in the table, we assumed pA/pR > 250, H0 = 8 10−6 %CD4 for animal p88, and H0 = 4 10−6 %CD4 for the six control animals from Ref. (Letvin et al., 2006). Other parameter values are fixed (Table 1).
V | pR | c–d | P0 | IR(0)/Pcut | Ti/SA | |
---|---|---|---|---|---|---|
Animal ID | 107 copies/ml/%CD4 | RNA (days %CD4)−1 | 1/day | 10−3 %CD4 | cells | days |
p88, Ref. (Kuroda et al., 1999) | 0.48 | 1.40 | 0.96 | 130 | 10 | 36 |
M-575 | 0.11 | 0.65 | 0.47 | 200 | 400 | 24 |
M-588 | 0.17 | 0.50 | 0.42 | 10 | 800 | 31 |
AC-04 | 1.86 | 0.55 | 0.45 | 17 | 200 | 33 |
AV-7G | 0.62 | 0.60 | 0.47 | 12 | 200 | 67 |
44-I | 1.00 | 0.75 | 0.45 | 17 | 200 | 40 |
64-I | 2.71 | 0.50 | 0.47 | 50 | 120 | 33 |