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. 2010 Mar 1;137(5):775–784. doi: 10.1242/dev.042101

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Fig. 4. — SG development in mice with SoxC deficiencies. (A-L) Immunohistochemistry was performed with antibodies directed against Th on transverse thoracic-level sections of wild-type (A,E,I), Sox4^Δ^/^Δ (B,F,J), Sox11^lacZ/lacZ (C,G,K) and Sox4^Δ^/^Δ; Sox11^lacZ/lacZ (dko) (D,H,L) embryos at 11.5 (A-D), 14.5 (E-H) and 18.5 (I-L) dpc. (M) The average Th-positive SG area per section was determined from immunohistochemical stainings in wild-type (black), Sox4^Δ^/^Δ (blue), Sox11^lacZ/lacZ (green) and Sox4^Δ^/^Δ; Sox11^lacZ/lacZ (dko, red) embryos at 11.5, 14.5 and 18.5 dpc. Area sizes are presented relative to the wild-type size at 18.5 dpc, which was set to 100. Reductions in size relative to the age-matched wild type were statistically significant (P<0.001, Student's t-test) for all ganglia except for Sox11^lacZ/lacZ ganglia at 18.5 dpc. (N) Average cell numbers within the ganglia per section were determined by counting DAPI-positive nuclei. Reductions in cell number relative to the age-matched wild type were statistically significant (P<0.001, Student's t-test) for all ganglia except Sox4^Δ^/^Δ ganglia at 11.5 and 14.5 dpc, and Sox11^lacZ/lacZ ganglia at 18.5 dpc.