Figure 1.

Chromatographic profile of fluconazole in plasma. Chromatograms: (A) Blank plasma. (B) Spiked blank plasma extracts Lower limit of detection (0.4 μg mL⁻¹); (C) Low standard (2.2 μg mL⁻¹) and (E) Medium standard (25.0 μg mL⁻¹). (D) Plasma extract of Patient #3 (15.0 μg mL⁻¹). Retention times: 9.3 min. (fluconazole) and 13.2 min (carbamazepine, internal standard).