Table 3.

Percentage volume change over 1 year in the AD group

	Longitudinal change (%)	p
Volumetric ROIs
Accumbens	−2.02	<10−19
Amygdala	−3.79	<10−19
Brainstem	−0.65	<10−16
Caudate	−1.49	<10−13
Cerebellum GM	−0.99	<10−25
Cerebellum WM	−0.95	<10−18
Cerebral WM	−1.42	<10−30
Hippocampus	−3.75	<10−35
Pallidum	−0.90	<10−15
Putamen	−1.45	<10−22
Thalamus	−1.51	<10−28
Ventricular ROIs
Lat vent	10.35	<10−28
Inf lat vent	16.26	<10−33
3rd ventricle	6.82	<10−21
4th ventricle	1.61	<0.001
Surface ROIs
Cingulate, caudal ant	−1.14	<10−17
Cingulate, rostral ant	−1.20	<10−18
Cingulate, posterior	−1.57	<10−21
Cingulate, isthmus	−1.54	<10−23
Frontal, superior	−1.20	<10−15
Frontal, caudal middle	−1.60	<10−20
Frontal, rostral middle	−1.23	<10−15
Frontal, pars opercularis	−1.31	<10−18
Frontal, pars triangularis	−1.10	<10−17
Frontal, pars orbitalis	−1.06	<10−<10
Frontal, lateral orbital	−1.47	<10−18
Frontal, medial orbital	−1.19	<10−17
Frontal, pole	−1.38	<10−10
Parietal, precentral gyrus	−0.69	<10−10
Parietal, postcentral gyrus	−0.27	0.01
Parietal, paracentral gyrus	−0.76	<10−11
Parietal, superior	−1.26	<10−18
Parietal, inferior	−2.10	<10−27
Parietal, supramarginal	−1.74	<10−21
Parietal, precuneus	−1.61	<10−24
Temporal, parahippocampal	−2.05	<10−34
Temporal, entorhinal	−2.42	<10−36
Temporal, pole	−2.54	<10−26
Temporal, superior	−1.63	<10−23
Temporal, middle	−2.87	<10−31
Temporal, inferior	−2.97	<10−32
Temporal, transverse	−0.59	<10−6
Temporal, banks sup temp sulc	−2.53	<10−28
Temporal, fusiform	−2.15	<10−33
Occipital, lateral	−0.96	<10−19
Occipital, pericalcarine	−0.16	>0.01n.s.
Occipital, lingual	−0.67	<10−15
Occipital, cuneus	−0.50	<10−9

n.s., Not significant. Ant, Anterior; inf, inferior; lat, lateral; sulc, sulcus; sup, superior; temp, temporal; vent, ventricle.