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. 2009 Nov 8;459(4):569–577. doi: 10.1007/s00424-009-0748-x

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© The Author(s) 2009

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Fig. 2 — HIF-1α does not affect cardiac hypertrophy after transverse aortic constriction (TAC) in female and male mice. a Sustained pressure overload was induced in female Hif-1α^+/+ and Hif-1α^+/− mice by TAC. Subsequently, posterior wall thickness (PWT) and septum thickness (ST) were analyzed up to 11 weeks by echocardiography. ^# p < 0.05 (TAC-treated Hif-1α^+/+ versus non-treated/pre Hif-1α^+/+ mice), *p < 0.05 (TAC-treated Hif-1α^+/− versus non-treated/pre Hif-1α^+/− mice). b Sustained pressure overload was induced in male Hif-1α^+/+ and Hif-1α^+/− mice by TAC. Subsequently, PWT and ST were analyzed up to 11 weeks by echocardiography. ^# p < 0.05 (TAC-treated Hif-1α^+/+ versus non-treated/pre Hif-1α^+/+ mice), *p < 0.05 (TAC-treated Hif-1α^+/− versus non-treated/pre Hif-1α^+/− mice)