Fig. 3.

Sequence alignment of Dictyostelium and human alpha-kinases. Dictyostelium and human alpha-kinase amino acids sequences corresponding to the human TRPM7 alpha-kinase domain (G1579-T1830) were aligned using ClustalW2 sequence alignment software [153]. Names and species, Dictyostelium discoideum (Dd), Homo sapiens (Hs) are indicated on the left. Conservation of specific residues within this group of alpha-kinases, corrected for missing sequences, is indicated by shadings of blue and a barchart supporting the alignement (0 not conserved, 100 fully conserved). Red bars represent fully conserved residues and are indicated red in Fig. 2. Sequences representing the P-loop and GXGXXG motif are indicated on top. The indicated residue identities refer to the human TRPM7 amino acid sequence