Table 1. Expression of IFN response genes in rheumatoid arthritis (RA) synovial macrophages.
| Description | Gene symbol | Fold increase RA vs. control | Mean signal intensity in RA |
|---|---|---|---|
| IFN-α-inducible protein 27 | IFI27 | 12.88 | 1,092 |
| Guanylate-binding protein 1, IFN-inducible, 67 kDa | GBP1 | 7.2 | 527 |
| IFN-induced transmembrane protein 1 (9–27) | IFITM1 | 5.9 | 906.6 |
| Signal transducer and activator of transcription 1, 91 kDa | STAT1 | 3.3 | 943 |
| Eukaryotic translation initiation factor 2-α kinase 2 | EIF2AK2 | 2.5 | 1,500 |
| IFN-induced protein with tetratricopeptide repeats 3 | IFIT3 | 2.2 | 1,001 |
| Chemokine (C-X-C motif) ligand 9 | CXCL9 | 80.5 | 33 |
| Indoleamine-pyrrole 2,3 dioxygenase | INDO | 6.8 | 499 |
| Chemokine (C-X-C motif) ligand 10 | CXCL10 | 6.2 | 282 |
| Chemokine (C-X-C motif) ligand 11 | CXCL11 | 5.7 | 81 |
| IRF1 | IRF1 | 3.2 | 983 |
| TNF (TNF superfamily, member 2) | TNF | 3.95 | 702 |
| INF-α41 | IFNA4 | 2.1 | 4.75 |
| INF-β1, fibroblast1 | IFNB1 | 2.8 | 11.75 |
Listed genes were elevated 2-fold or more in RA synovial macrophages (n = 5) relative to control macrophages isolated from peripheral blood of healthy donors (samples were pooled into 3 sets, 5 donors each), p < 0.05 (Welch's t test or Welch's analysis of variance with the Benjamini-Hochberg correction for false discovery rate multiple testing).
1
Expression levels were low. Difference was not statistically significant.