Figure 4. Core perturbs innate inflammatory and antiviral signal transduction.

One-hundred nanograms of core genes were co-transfected with luciferase reporter genes under control of NF-κB (panel A), or ISRE (panel B) promoters. Twenty-four hours post-transfection, cells were treated with 10ng/ml TNF-α or 100u/ml of IFN-α (Roferon) for 4 hours before luciferase activity was measured by Britelite assay. Error bars represent standard deviations of quadruplicate transfections.