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. Author manuscript; available in PMC: 2011 Jan 12.
Published in final edited form as: Biochemistry. 2010 Jan 12;49(1):84–94. doi: 10.1021/bi901790e

Table 4.

Selected Average Distances rA–B (Å) between Oxoenamino or Hydroxyimino Tautomer of PLP(H+)–L-Dopa Schiff Bases and Enzyme Residues in the Active Site of DDC

PLP(H+)–L-dopa residue oxoenamine hydroxyimine X-ray
O3 Hγ1, Thr246 2.00±0.13 3.41 ± 0.21
H Oγ1, Thr246 3.61 ± 0.25 2.05±0.29
O3 Oγ1, Thr246 2.83 ± 0.12 2.87±0.17 3.03
H1 Oδ1, Oδ2, Asp271 1.99 ± 0.23 2.01 ± 0.22
N1 Oδ1, Oδ2, Asp271 2.89 ± 0.16 2.91 ±0.17 2.78
C4A Hε2, His192 3.95 ± 0.23 3.65±0.27 3.99
Cα Hε2, His192 4.63 ± 0.23 5.19 ± 0.29
OCO2 Hε2, His192 3.77± 0.28 4.28±0.39
C4A Nζ, Lys303 3.50± 0.18 4.01 ± 0.27 2.84
N Hζ, Lys303 3.86 ± 0.27 3.00±0.41
H Nζ, Lys303 4.80± 0.26 5.73±0.44
OCO2 Hη, Tyr332B 1.86±0.13 1.91 ±0.16