. Author manuscript; available in PMC: 2010 Jul 1.

Published in final edited form as: Chem Rev. 2009 Jul;109(7):2880–2893. doi: 10.1021/cr900028p

Table 1.

FDA Approved Purine and Pyrimidine Antimetabolites

drug	date approved
5-aza-2′-deoxycytidine (decitabine)	2006
O⁶-methylarabinofuranosyl guanine (nelarabine)	2005
2′-fluoro-2′-deoxyarabinofuranosyl-2-chloroadenine (clofarabine)	2004
5-aza-cytidine (vidaza)	2004
N⁴-pentyloxycarbonyl-5′-deoxy-5-fluorocytidine (capecitabine)	1998
2,2-difluoro-2′-deoxycytidine (gemcitabine)	1996
2-chloro-2′-deoxyadenosine (cladribine)	1992
arabinofuranosyl-2-fluoroadenine (fludarabine)	1991
2′-deoxycoformycin (pentostatin)	1991
5-fluoro-2′-deoxyuridine (floxuridine)	1970
arabinofuranosylcytosine (cytarabine)	1969
6-thioguanine	1966
5-fluorouracil	1962
6-mercaptopurine	1953