Table 1.
Demographic and Clinical Characteristics of Patients with Venous Thromboembolism According to Bleeding Status
| Bleeding (+) (n= 228) |
Bleeding (-) (n=1,669) |
P-value | |
|---|---|---|---|
| Demographic Characteristics | |||
| Age, mean (years) | 70.4 | 63.6 | <0.001 |
| Female (%) | 61.8 | 54.2 | 0.03 |
| Hospitalization history (%) | |||
| Admitted with non-VTE diagnosis | 35.1 | 27.1 | 0.04 |
| Other hospitalization in prior 3 months | 42.1 | 38.5 | 0.57 |
| Recent (< 3 mo) medical conditions (%) | |||
| Surgery | 28.6 | 27.7 | 0.93 |
| Malignancy | 36.8 | 28.9 | 0.01 |
| Severe infection | 31.6 | 25.2 | 0.04 |
| Central venous catheter | 22.4 | 17.9 | 0.11 |
| ICU discharge | 21.5 | 15.8 | 0.03 |
| Intubation | 18.0 | 15.5 | 0.33 |
| Fracture | 15.4 | 10.3 | 0.03 |
| Chemotherapy | 9.7 | 8.0 | 0.41 |
| Heart failure | 8.8 | 8.0 | 0.68 |
| Trauma | 20.2 | 13.8 | 0.01 |
| Cardiac procedures | 4.8 | 4.3 | 0.70 |
| Other medical history (%) | |||
| Prior VTE | 18.4 | 17.3 | 0.67 |
| Prior IVC filter | 9.7 | 7.8 | 0.34 |
| Prior CVA | 12.7 | 12.0 | 0.75 |
| Diabetes | 24.4 | 18.5 | 0.02 |
| Hypertension | 63.2 | 51.4 | <0.001 |
| Ischemic heart disease | 28.5 | 20.4 | 0.006 |
| Inflammatory bowel disease | 4.0 | 1.9 | 0.07 |
| Liver disease | 1.8 | 1.0 | 0.31 |
| Chronic renal insufficiency | 7.9 | 6.0 | 0.47 |
| Dialysis dependent | 4.0 | 2.0 | 0.09 |
| Laboratory data | |||
| Cr (mg/dl) | 1.43 (SD 1.21) |
1.21 (SD 1.10) |
0.008 |
| Hematocrit (%) | 34.2 (SD 5.3) |
36.1 (SD 5.8) |
<0.001 |
| Platelets | 245.7 (SD 107.5) |
250.2 (SD 110.4) |
0.58 |
| Type of VTE (%) | |||
| Isolated DVT | 66.2 | 72.0 | 0.08 |
| PE with or without DVT | 33.9 | 28.0 | |
| Unprovoked | 18.4 | 23.9 | 0.03 |
| Malignancy-related | 36.8 | 28.9 | 0.02 |
| Acute parenteral treatment (%) | |||
| UFH | 42.6 | 37.5 | 0.002 |
| LMWH | 29.3 | 30.7 | |
| Both UFH and LMWH | 18.5 | 13.5 | |
| Other parenteral therapy | 4.8 | 1.6 | 0.004 |
| Acute warfarin utilization | 71.1 | 73.0 | 0.54 |
Recent - occurring or active in the 3 months prior to index DVT or PE
Severe infection = infections were limited to those involving the blood, bone and joint, central nervous system, cardiovascular system, gastrointestinal system, respiratory system (pneumonia only), surgical sites, or the skin.
Unprovoked VTE = Any VTE in which there is NO recent fracture, recent trauma, recent surgery, recent hospitalization, current hospitalization, central venous catheter, pregnancy, hormonal therapy, or malignancy
Provoked VTE = Any VTE occurring within 3 months of fracture, trauma, surgery, hospitalization, central venous catheter placement, pregnancy, hormonal therapy. Patients with active malignancy at the time of VTE were not included in this category.
ICU = intensive care unit
VTE = venous thromboembolism
IVC = inferior vena cava
CVA = cerebrovascular accident
Cr = creatinine
DVT = deep vein thrombosis
UFH = unfractionated heparin
LMWH = low-molecular weight heparins (enoxaparin and dalteparin)