Fig. 3.
Corticobasal degeneration. a A swollen achromatic neuron (arrow) in the middle frontal gyrus. Hematoxylin and eosin (HE). b Tau-positive neurofibrillary tangles in the pyramidal neurons of the CA1 hippocampal subfield. c A globose neurofibrillary tangle (arrow) in the locus coeruleus. d An astrocytic plaque (asterisk), coiled body (arrow), and threads (arrowhead) in the deep cortical laminae and white matter of the parietal lobe. b, c, d Anti-phosphorylated tau (PHF1) immunohistochemistry. Bars 10 μm