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. 2009 Dec 23;35(4):976–989. doi: 10.1038/npp.2009.201

Figure 1.

Figure 1

MPEP reduced self-grooming behavior in BTBR. Cumulative time spent self-grooming was scored over a 10-min session, for the data shown in Figures 1 and 5. (a) B6 mice did not show any significant differences in the amount of time spent self-grooming after treatment with saline vehicle or MPEP at doses of 0.5 mg/kg, 1.0 mg/kg, 10 mg/kg, or 30 mg/kg i. p. (b) BTBR showed significant reductions in their innately high levels of repetitive self-grooming after treatment with MPEP at doses of 1.0 mg/kg, 10 mg/kg, and 30 mg/kg, *p<0.05 as compared with saline. N=6–10 per dose for each strain. Data are shown as ± SEM in all figures. Significant differences are as compared with vehicle treatment in all figures. Please see Results section for individual post hoc comparisons and statistics for all figures.