Figure 3.

B6 sociability was unaffected by MPEP administration. Social approach was assayed in an automated photocell-equipped three-chambered arena, along with observer scoring of direct sniffing interactions from videotapes of the social approach session, in Figures 3, 4, 7, and 8. (a) B6 showed normal sociability as expected, defined as more time in the side chamber with the novel mouse than in the side chamber with the novel object, after saline and MPEP treatments, ^*p<0.05. (b) B6 showed significantly more time spent sniffing the novel mouse than the novel object, after saline and MPEP treatments, ^*p<0.05 (c) B6 showed no difference in number of entries into the side chambers after MPEP treatment, indicating no drug effect on general exploratory activity during the social approach task. (d) B6 showed no innate chamber side bias during the 10-min habituation phase before the start of the sociability test. N=8–10 per dose.