Figure 5.

Functional impact of somatic TP53 mutations in human cancers. (A) Scatter plots showing the frequency (x-axis) of single amino-acid substitutions in relation to their effect (left panel) or functional impacts on transactivation (right panel), and expected substitution rates (y-axis in log). Each point represents a single amino-acid substitution that is shaped and colored according to the mutation effect or functional impact. (B) Pie charts displaying the proportion of all somatic single amino-acid substitutions according to their effect (left panel) or functional impacts on transactivation (right panel). Data from the IARC TP53 Database (R13, November 2008)(Petitjean et al. 2007b).