Table 2.

Regions of activation in comparisons of negative valence to neutral valence conditions: men compared with women in the early follicular and midcycle menstrual phases

Hypothesized regions		x	y	z	Z	Voxels	FWEap value
Region	Hemisphere
Early follicular (men > women)
Amygdala	L	−18	−4	−14	2.92	27	0.32
Amygdala	R	20	0	14	2.74	18	0.41
ACG
BA 32	R	14	16	26	3.75**	14	0.47
BA 32	L	−2	22	28	3.52**	18	0.41
Midcycle/ovulation (men > women)
Cortical regions
ACG
BA 32	R	12	34	28	2.93	14	0.48
BA 24	L	−4	32	8	3.12**	27	0.32
BA 24	L	−2	18	20	2.71	12	0.51
BA 24	R	4	32	8	2.63	6	0.66
BA 24	R	4	18	20	2.79	16	0.45
OFC
BA 10	R	34	58	−4	4.06**	83	0.09
BA 11	R	2	40	−22	2.72	6	0.66
BA 47	R	24	18	−18	2.98	9	0.58
BA 47	R	40	28	−20	3.66**	197	0.01
BA 47	L	−46	26	−8	3.73**	137	0.03
vmPFC
BA 10	L	−4	42	−20	3.25**	33	0.19
BA 10	R	4	54	−8	3.19**	86	0.08
medPFC
BA 10	R	20	66	10	5.02**	189	0.005
BA 10	L	−4	64	20	3.62**	56	0.09
medPFC/sFG
BA 10	R	34	58	−4	4.06**	66	0.07
Subcortical regions
Amygdala	L	−18	−2	−14	3.22**	41	0.22
Hippocampus	R	30	−24	−8	4.28**	308	0.003
Hypothalamus
VMNb	L	−4	2	−6	2.48	3	0.77
Brainstem
PAG		2	−30	−2	2.96	60	0.14

Voxelwise Z-score significance level is shown. **p ≤ 0.001, uncorrected for multiple comparisons within a hypothesized ROI; ROIs listed represent regions of significantly activated clusters within the a priori hypothesized ROI. BA, Brodmann area; medPFC, medial prefrontal cortex; sFG, superior frontal gyrus.

^aFWE rate used for SVC: cluster-level significance level (FWE corrected within the search volume of interest).

^bVMN: derived from a 4 mm sphere around activation center; the region was identified by MNI coordinates and validated by neuroanatomist (N.M.). [Note: Left LHA, which was derived from a 4 mm sphere around activation center, had a significant Z-score at 2.47 (coordinates −4, −2, −8), but with only 1 voxel, and therefore was not included in the table above.]