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. 2010 Feb 1;120(3):756–767. doi: 10.1172/JCI36066

Figure 8. DGAT1 expression levels modulate M1-type activation of BMD-Mϕ by palmitate.

Figure 8

(A) Treatment with palmitate but not oleate increases M1 gene mRNA levels in WT BMD-Mϕ. mRNA levels were measured by qPCR (n = 3–6 per group; *P < 0.05). (B) Expression of M1 pathway genes from Dgat1–/–, WT, and aP2-Dgat1 BMD-Mϕ in medium alone (control) or after treatment for 24 hours with 150 μM palmitate (n = 3–7 per group; *P < 0.05 vs WT in the same treatment condition). (C) Levels of IL-6, MCP-1, and TNF-α in conditioned medium of control and palmitate-treated BMD-Mϕ (n = 6–7 per group; *P < 0.05 vs WT).

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