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. 2010 Feb 8;120(3):768–777. doi: 10.1172/JCI39569

Figure 3. The expression of inflammatory cytokines significantly decreased in the kidneys of Usag1–/–Col4a3–/– mice.

Figure 3

(A) Real-time RT-PCR analysis of inflammatory cytokine mRNA in the kidneys of WT littermates (WT/WT), Usag1+/+Col4a3–/– mice (WT/KO), and Usag1–/–Col4a3–/– mice (KO/KO) at 10 weeks of age. The expression levels were normalized to those of GAPDH and expressed relative to those of WT littermates (n = 10). Bars indicate the mean ± SD. *P < 0.001; **P < 0.01; ***P < 0.05. (B) Representative immunostaining for MCP-1 in the kidneys of WT littermates (WT/WT), Usag1+/+Col4a3–/– mice (WT/KO), and Usag1–/–Col4a3–/– mice (KO/KO) at 10 weeks of age. Scale bars: 100 μm.