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. 2010 Feb 15;120(3):720–734. doi: 10.1172/JCI39620

Figure 9. Insulin sensitivity and glucose homeostasis are improved in POMC-Ptp1b–/– mice.

Figure 9

(A) GTT for POMC-Ptp1b–/– mice and Ptp1b+/+ control mice on HFD (8 weeks old). (B) ITT for POMC-Ptp1b–/– mice and Ptp1b+/+ control mice on HFD (16 weeks old). (C) GTT for POMC-Ptp1b–/– mice and Ptp1b+/+ control mice on chow diet (16 weeks old). (D) ITT for POMC-Ptp1b–/– mice and Ptp1b+/+ controls on a chow diet (17 weeks old). Male mice (n = 8/genotype) were used for GTT and ITT experiments. Hyperinsulinemic-euglycemic clamp analysis of POMC-Ptp1b–/– mice on a chow diet reveals improved insulin sensitivity. Body weights (E), epididymal fat pad weights (F), and basal blood glucose (G) of male POMC-Ptp1b–/– mice (KO) and Ptp1b+/+ (WT) control mice on a chow diet were similar prior to clamp. (H) POMC-Ptp1b–/– mice have increased insulin sensitivity as shown by a greater GIR compared with Ptp1b+/+ controls. (I) POMC-Ptp1b–/– mice have a greater insulin-induced suppression of HGP during the clamp compared with controls (WT clamp vs. KO clamp). (J) POMC-Ptp1b–/– mice have increased Rd compared with Ptp1b+/+ controls. Male mice were 8 weeks of age on a chow diet (n = 8/group). All values are mean ± SEM. *P < 0.05, **P < 0.01 Ptp1b+/+ versus POMC-Ptp1b–/– by 2-tailed Student’s t test; #P < 0.05, Ptp1b+/+ versus POMC-Ptp1b–/– by AUC.