Table 2.
Comparison of the vasodilator effect of UK114,542 and quercetin against U46619-induced contractions of the porcine isolated coronary artery under various conditions
| 100 nM UK114,542 | 30 µM Quercetin | |
|---|---|---|
| Control (E+) | 50.3 ± 4.3 (n= 7) | 59.5 ± 11.1 (n= 6) |
| Denuded (E–) | 29.2 ± 6.2 (n= 7)* | 69.5 ± 13.0 (n= 6) |
| Control (E+) | 65.6 ± 5.5 (n= 7) | 61.6 ± 8.8 (n= 7) |
| 3 µM ODQ (E+) | 28.3 ± 9.0 (n= 7)* | 56.2 ± 10.2 (n= 7) |
| Control (E+) | 58.2 ± 12.0 (n= 8) | 80.3 ± 6.3 (n= 15) |
| 100 µM l-NAME (E+) | 4.0 ± 2.0 (n= 8)* | 52.3 ± 8.7 (n= 15)* |
A statistically significant difference between control and treatment conditions (P < 0.05, Student's paired t-test).
The responses shown are the percentage relaxations ± SEM (n= 6–15).