Figure 2.

The absence of nucleoside triphosphate diphosphohydrolase-1 (NTPDase1) reveals a potent hypotensive effect of nucleotides. (A) Time course of the vascular response on the mean arterial pressure to injections of 10 nmole·kg⁻¹ of ATP (upper panel) or UTP (lower panel) in wild-type (Entpd1^+/+) and Entpd1^−/− mice. (B) Concentration-response curves comparing the maximal decrease in mean arterial pressure (ΔMAP max) in response to i.v. injections of ATP (upper panel) or UTP (lower panel). Data are representative of the mean ± SEM of four to five experiments performed on different mice. *P < 0.05; **P < 0.01; ***P < 0.001.