Table 2.

Effects of indomethacin (indo) (1 µM), of the selective COX-1 inhibitor SC-560 (1 µM) and of the COX-2 inhibitor NS-398 (1 µM) on the vasoconstrictor responses to noradrenaline (NA) of penile arteries from LZR and OZR

	NA
	LZR		OZR
	pEC50	Emax (Nm−1)	n	pEC50	Emax (Nm−1)	n
NA	6.26 ± 0.12	3.0 ± 0.5	9	6.58 ± 0.01	2.1 ± 0.2	10
+Indo	6.57 ± 0.14**	2.9 ± 0.5	9	6.78 ± 0.15*	1.9 ± 0.2	10
NA	6.80 ± 0.10	2.8 ± 0.5	7	7.16 ± 0.18	2.2 ± 0.5	8
+SC-560	6.57 ± 0.11	2.9 ± 0.3	7	6.98 ± 0.40	2.1 ± 0.4	8
NA	6.51 ± 0.13	3.5 ± 0.3	12	7.00 ± 0.17	2.6 ± 0.3	9
+NS-398	6.69 ± 0.12**	3.5 ± 0.4	12	6.49 ± 0.17*	2.4 ± 0.3*	9

Values represent mean ± SE of the number n of individual arteries. pEC₅₀ is −logEC₅₀, being the concentration of agonist giving half maximal response (Emax). Significant differences from controls were analysed by a paired Student's t-test.

^*P < 0.05;

^**P < 0.01.

COX, cyclooxygenase; LZR, lean Zucker rats; OZR, obese Zucker rats.