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. 2010 Jan 22;159(3):698–708. doi: 10.1111/j.1476-5381.2009.00568.x

Figure 3.

Figure 3

Representative immunoblot analysis of the OATP1B3 mutants at position Lys28, Lys41 and Arg580. The total OATP1B3 expression of the mutants Lys28, Lys41 and Arg580, and the control mutant Gly522>Cys compared to the WT and VC are shown. The results of densitometric analyses are given below. The data are expressed as mean ± SEM in arbitrary units (a.u.). No significant differences in the protein expression (P > 0.05) of the control mutant (Gly522>Cys) and the other mutants except for Arg580>Ala (P < 0.05) compared to OATP1B3 WT were observed (one-way Anova with Dunnett's multiple comparison test). (A) Mutants of Lys41 and Lys28; (B) mutants of Arg580; (C) mutants of Lys28, Lys41 and Arg580 to alanine. *P < 0.05; different from WT.