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. 2010 Jan 22;159(3):698–708. doi: 10.1111/j.1476-5381.2009.00568.x

Figure 5.

Figure 5

OATP1B3-mediated (A) BSP (1 µM) and (B) pravastatin (50 µM) uptake (10 min) by mutant OATP1B3 proteins compared to the WT and vector-transfected HEK293 cells (VCs). The transport activity is expressed in percent relative to the WT transport activity (100%). Data were analysed by Anova with Dunnett's multiple comparison test (compared to WT) was performed (**P < 0.01; different from WT). The Lys>Gln and Lys>Gly mutants at position 41 showed reduced transport activity for pravastatin and/or BSP, whereas Lys41>Arg rescued the transport activity. The Arg580>Gly and Arg580>Lys mutants were characterized by a reduced uptake activity.