Figure 6.
Effect of Compound 21 (50 ng·kg−1·min−1; 4 h infusion shown by full line), low-dose candesartan (0.01 mg·kg−1 bolus i.v.; shown by an arrow), Compound 21 + candesartan and Compound 21 + candesartan + PD123319 (50 µg·kg−1·min−1 for 2 h; shown by dashed line), on mean arterial pressure (MAP) in spontaneously hypertensive rat (n= 7). Values represent mean ± SEM. *P < 0.05 for treatment effect between Compound 21 and candesartan; #P < 0.001 for overall effect of individual treatment versus Compound 21 (two-way repeated measures anova); †P < 0.01 for treatment effect between Compound 21 + candesartan and candesartan alone (two-way repeated measures anova).