Table 4. Determination of sensitivity and specificity of HA and HYAL-1 staining inferences for predicting biochemical recurrence.

The sensitivity, specificity and accuracy for HA and HYAL-1 staining inferences in biopsy and radical prostatectomy specimens were calculated using the cut-off limits determined from the ROC curves and then cross-validated. The data presented in the parentheses are mean values and 95% CI, derived from the cross validation analyses.

Parameter	Area Under the Curve	Sensitivity	Specificity	Accuracy
HA (Biopsy)	0.77	72.7% (71.5%; 95% CI: 60.5 – 76.5)	63.7% (63.9%; 95% CI: 60.4 – 72.2)	68.2% (67.7%; 95% CI: 62.9 – 75.3)
HA (prostatectomy)	0.79	90.9% (85.8%; 95% CI: 80.6 – 93.5)	55.2% (56.3%; 95% CI: 51.7 – 63.8)	73% (71.8%; 95% CI: 67.6 – 77.4)
HYAL-1 (Biopsy)	0.87	81.8% (82.3%; 95% CI: 76.6 – 92.3)	81.8% (81.9%; 95% CI: 76.3 – 86.8)	81.8% (81.4%; 95% CI: 76.9 – 88.4)
HYAL-1 (prostatectomy)	0.95	90.9% (88.9%; 95% CI: (81.3 – 95.6)	75% (76.6%: 95% CI: 72.3 – 81.4)	83% (82.6%; 95% CI: 77.1 – 87.5)