Fig. 1.
cpg15-2 is a new cpg15 paralogue. A: Alignment of the mouse CPG15 and CPG15-2 predicted amino acid sequences. Identical residues are marked by asterisks, and similar residues are marked by dots. Conserved cysteines are boxed. Predicted signal peptides at the N-termini and glycosylphosphatidylinositol (GPI) anchoring signals at the C-termini are underscored. Exon/intron boundaries are marked by arrows. B: Comparison of mouse cpg15 and mouse cpg15-2 genomic structures. Exons, indicated by solid boxes, are numbered in sequence. C: Phylogenetic analysis of the cpg15 gene family of selected species. All the family members in various species belong to either the cpg15 branch or the cpg15-2 branch. Accession numbers are indicated in parentheses. See Supplemental Table 2 for a complete list of known cpg15 gene family members.