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. 2009 Dec 21;588(Pt 4):651–670. doi: 10.1113/jphysiol.2010.183798

Figure 6. INaR activation kinetics is not affected by Scn8a knockout.

Figure 6

A, voltage dependence of INaR time to peak (TTP) in WT (open circles) and Snc8a KO (filled circles) CG cells (n= 15 and 13 for WT and KO, respectively). B, currents recorded in response to the INaR activation protocol (see Fig. 4A) at three different repolarisation potentials (−20, −40 and −70 mV) in a representative WT neuron (cell A8514), and biexponential fittings (enhanced lines) of INaR activation and decay phases. Fitting parameters are: A1= 37.6 pA, τ1= 1.33 ms, A2=−50.1 pA, τ2= 21.3 ms, C=−13.2 pA (−20 mV); A1= 130.0 pA, τ1= 3.25 ms, A2=−166.3 pA, τ2= 20.2 ms, C=−15.4 pA (−40 mV); A2=−24.0 pA, τ2= 2.88 ms, C= 0.0 pA (−70 mV). C, voltage dependence of INaR activation time constant, τact (equivalent to panel B's τ1) (Ca), and INaR decay time constant, τdecay (equivalent to panel B's τ2) (Cb), in WT (open circles) and Snc8a KO (filled circles) CG cells (n= 15 and 13 for WT and KO, respectively).