Table 4.
Clinical Measurements and Metabolic Syndrome Diagnostic Criteria among Overweight/Obese Breast Cancer Survivors (n = 42)
| n (%) | Mean (SD) | Median | Range | Healthy normal | |
|---|---|---|---|---|---|
| Metabolic biomarkers | |||||
| Fasting glucose (mg/dL) | 98.7 (12.9) | 98 | 78–149 | ≤100 mg/dL | |
| OGTTa at 2 hours (n = 23) | 119.0 (32.4) | 113 | 62–192 | <140 mg/dL at 2 hours | |
| Insulin (uU/mL) | 16.1 (13.2) | 13 | 4–82 | 5–20 uU/mL | |
| Glycosylated hemoglobin (HbA1c) (%) | 6.0 (0.5) | 5.8 | 5.1–7.4 | ≤5% | |
| Thyroid-stimulating hormone (mIU/L) | 2.1 (1.4) | 1.7 | 0.4–7.4 | 0.4–4.0 mIU/L | |
| Lipid biomarkers | |||||
| Triglycerides (TG) (mg/dL) | 129.4 (55.7) | 120 | 52–275 | <150 mg/dL | |
| Total cholesterol (mg/dL) | 199.9 (33.7) | 199 | 104–285 | <200 mg/dL | |
| HDL cholesterol (mg/dL) | 57.7 (17.5) | 56 | 26–109 | ≤50 mg/dL | |
| LDL cholesterol (mg/dL) | 116.4 (28.6) | 109 | 57–190 | <130 mg/dL | |
| Total cholesterol/HDL cholesterol ratio | 4.7 (6.4) | 3.8 | 2–45 | 5:1 | |
| Inflammatory biomarker | |||||
| C-reactive protein (hsCRP, mg/L)b | 5.1 (5.3) | 3.8 | 0.6–33.6 | <1 mg/L | |
| Hyptertensive indicators | |||||
| Systolic blood pressure (mmHg) | 129.9 (18.1) | 129 | 101–190 | <130 mmHg | |
| Diastolic blood pressure (mmHg) | 79.1 (11.5) | 78 | 47–104 | <85 mmHg | |
| Classification of metabolic syndrome | |||||
| International Diabetes Foundation (IDF) diagnosticc | 23 (54.8%) | 2.5 (1.2) | 3 | 0–5 | <3 |
a
OGTT, oral glucose tolerance test; TG, triglycerides; HDL, high-density lipoprotein; LDL, low-density lipoprotein.
b
High sensitivity C-reactive protein (hsCRP) healthy normal range indicates low risk of cardiovascular disease, 1–3 mg/L moderate risk, >3 mg/L high risk.
c
For IDF diagnostic, patient must have 3 or more of the following: TG ≥150 mg/dL, waist circumference >88 cm, fasting glucose ≥100 mg/dL (revised based on American Diabetes Association recommendation for glucose cut point) or diabetes medication, systolic or diastolic blood pressure ≥130 or 85 mmHg, respectively, HDL ≤50 mg/dL.