Figure 3.

Nucleokinesis in migrating neurons. Nucleokinesis involves both perinuclear and nucleus translocation. First, the perinuclear dilatation containing the centrosome and the Golgi apparatus move forward. The perinuclear microtubular cage (in green) pulls the nucleus forward until reaching the swelling. Forward pulling forces (green arrow) are complemented by myosin II at the rear, which generates pushing forces (red arrows) to move the nucleus in its characteristic saltatory pattern of nucleokinesis. Many motor proteins and other proteins related to the cytoskeleton are implicated in the process. (N) nucleus.