Table 1.

Protein and RNA components of the PNC

Component Name	Brief Description
Protein components
CUG-BP	Binds polyadenylated RNA and is involved in alternative splicing, deadenylation, and mytonic dystrophy (Timchenko et al. 1996; Savkur et al. 2001; Ho et al. 2005)
KSRP	Involved in alternative splicing, splicing regulation, and RNA decay (Min et al. 1997; Nechama et al. 2008)
Nucleolin	Enriched in the nucleolus and PNC, plays a role in rDNA transcription and RNA processing (Ginisty et al. 1999; Tuteja and Tuteja 1998)
PTB	Protein involved in pre-mRNA splicing, alternative splicing, RNA polyadenylation, and translation (Lou et al. 1996; Stoneley and Willis 2004; Wagner and Garcia-Blanco 2001)
Raver1/2	RNA binding, nuclear RNPs that interact with PTB (Kleinhenz et al. 2005)
ROD1	Shares homology with PTB and is a homolog to yeast regulator of differentiation (Yamamoto et al. 1999)
RNA Components
Alu RNA	Forms Alu complex that is implicated in regulation of transcription and translation (Hasler and Strub 2006a; Hasler and Strub 2006b)
hY RNA	Interacts with Ro protein to form Ro ribonucleoproteins (RNPs) (Wolin and Steitz 1984)
MRP RNA	RNA portion of the MRP RNP, which plays a role in mitochondrial DNA replication and preribosomal RNA processing (van Eenennaam et al. 2000)
RNase P RNA	RNA component of RNase P complex, involved in maturation of 5′ end of tRNA (van Eenennaam et al. 2000)
SRP RNA	Part of the signal recognition particle, implicated in secretory protein transport and elongation arrest (Wolin and Walter 1989)