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Cartoon showing the two types of metal-binding sites in the SmtB/ArsR family depicted on the CadC structure. The α3N sites are located on opposite ends of the dimer and are formed by thiolate groups (orange circles) from helix H3 in one monomer and the N-terminal region of the other monomer. The α5 sites are located on the dimeric interface and are formed by carboxylate (red circles) and imidazole (blue circles) side chains contributed by the H5 helix from each monomer.
