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. 2010 Jan 27;10:13. doi: 10.1186/1471-213X-10-13

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Copyright ©2010 Burgess et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Cell proliferation in Ras transgenic mice. BrdU (A-D) and Ki67 (E-H) immunohistochemistry was performed on nontransgenic (NT) (A, C, E, G) and Pax6-Ras transgenic (B, D, F, H) embryos of age E11.5 (A, B, E, F) and E13.5 (C, D, G, H). Antigen antibody complexes are in red and nuclei are stained blue with DAPI. Quantification of the BrdU proliferation index is shown in panel I. Ras transgenic lens epithelial cells showed a significant increase in BrdU incorporation at E11.5 (I) but not at E13.5 (I). The number of sections counted for each genotype and time point are indicated in the graph. Error bars indicate standard deviation. Asterisk in the graph indicates a significance of P < 0.05. The scale bar (G) represents 50 μm in panels A, B, E-H and 100 μm in panels C, D.