Table 1.

Proteins tested for their effect on prion replication.

Protein tested	Reason of interest	Reference	Results
Amyloid beta (A4) precursor protein (App)	mouse orthologs colocalize with PrPC; human orthologs are associated with AD	(Farrer et al., 1997, Schmitt-Ulms et al., 2004)	Table 2
Human APP695 Amyloid beta (A4) precursor-like protein (Aplp2) Human Apolipoprotein E (APOE), ε3 and ε4 alleles
Interleukin 10 (IL-10)	elevated in CJD patients	(Stoeck et al.,2005)	Table 3
Interleukin-1 receptor, type I (IL-1R1)	elevated levels of IL-1α, IL-1β, and TNF-α in prion-infected mice and CJD patients	(Campbell et al., 1994, Sharief et al.,1999)
Tumor necrosis factor (TNF-α)
Transforming growth factor-β1 (TGF-β1)	elevated in prion-infected mice	(Baker et al., 1999)
Chemokine (C-C motif) receptor 2 (CCR2)	associated with microglial activation in prion disease; elevated levels of CCL2, CCL5, and CCR5 in prion-infected mice	(Baker et al., 1999, Felton et al., 2005, Lee et al., 2005, Marella & Chabry,2004)
Chemokine (C-C motif) receptor 5 (CCR5)
Methionine sulfoxide reductase A (MsrA)	putative SOD activity of PrPC	(Moskovitz & Stadtman, 2003, Wong et al., 1999)	Table 4
Methionine sulfoxide reductase B (MsrB)
Human superoxide dismutase 1 (SOD1)	putative SOD activity of PrPC	(Wong et al., 1999)
Human heat shock protein 70 (Hsp70)	elevated in prion-infected mice and Purkinje cells of CJD patients	(Kenward et al., 1994, Kovacs et al., 2001)
Mannoside-b1,4-N-acetylglucosaminyltransferase III (Mgat3)	affects PrP glycosylation in prion disease; associated with AD	(Fiala et al., 2007, Rudd et al., 1999)
Caveolin-1	involved in PrP-mediated cellular signaling	(Mouillet-Richard et al., 2000, Santuccione et al., 2005)	Table 5
Fyn kinase
Receptor protein tyrosine phosphatase α (RPTPα)
Doppel (DpI)	paralog of PrP; induces ataxia when cerebrally expressed in Prnp−/− mice	(Moore et al., 1999)
CD9	elevated in prion-infected mice and CJD patients	(Doh-ura et al., 2000)