. Author manuscript; available in PMC: 2010 Feb 24.

Published in final edited form as: J Gen Virol. 2008 Jul;89(Pt 7):1777–1788. doi: 10.1099/vir.0.2008/001255-0

Table 3.

Prion transmission to mouse models relevant to inflammation.^*

Protein	Mice	Strain	Median incubation time (days)	n^†	p_L	p_WG	Relative time (95% c.i.)

IL-10	B6-IL10^−/− C	57BL/6J	111	6	<0.001	<0.001	0.814 (0.724–0.916)
	wt	C57BL/6J	145	82^‡	<0.001	<0.001	0.814 (0.724–0.916)

	129-IL10^−/− 129S	6	130	8	0.001	0.718	0.978 (0.867–1.103)
	wt	129S1/SvlmJ	133	8	0.001	0.718	0.978 (0.867–1.103)

IL-1R1	Il1r1^−/−	129S1/Sv and C57BL/6	159	10	<0.001	0.012	1.164 (1.035–1.309)
	Il1r1^+/−	129S1/Sv, C57BL/6, and B6129SF2/J	148 10		0.009	0.332	1.061 (0.941–1.197)
	wt	B6129SF2/J	138	10^§	0.009	0.332	1.061 (0.941–1.197)

TNF-α	Tnf^−/− C	57BL/6	149	15	0.008	0.432	0.954 (0.848–1.073)
TNF-α	wt	C57BL/6J	162	12	0.008	0.432	0.954 (0.848–1.073)

TNF-R1 and TNF-R2	Tnfrsf1a^−/− Tnfrsf1b^−/−	129S7/SvEvBrd and C57BL/6	126	9	0.001	0.341	0.944 (0.839–1.063)
	Tnfrsf1a^+/− Tnfrsf1b^+/−	129S7/SvEvBrd, C57BL/6, and B6129SF2/J	132 10		<0.001	0.315	0.942 (0.838–1.059)
	wt	B6129SF2/J	138	10^§	<0.001	0.315	0.942 (0.838–1.059)

TGF-β1	Tg(Tgfb1) S	JL/J	99	5
	wt	SJL/J		5

	Tgfb1^+/− N	IH/Ola	124	8	0.990	0.353	1.060 (0.937–1.200)
	wt	NIH/Ola	124	6	0.990	0.353	1.060 (0.937–1.200)

TGF-β type II receptor, kinase deficient (TβRIIΔk)	Tg(TβRIIΔk)^+/− × Tg(tTA)^+/− Prnp^+/−	C57BL/6J and FVB/N	355	7	0.523	0.857	1.011 (0.894–1.145)
TGF-β type II receptor, kinase deficient (TβRIIΔk)	Tg(TβRIIΔk)^+/− × Tg(tTA)^−/− Prnp^+/−	C57BL/6J and FVB/N	287	6	0.523	0.857	1.011 (0.894–1.145)

CCR2	Ccr2^−/− C	57BL/6J	141	20	0.827	0.456	1.04 (0.934–1.166)
CCR2	wt	C57BL/6J	145	82^‡	0.827	0.456	1.04 (0.934–1.166)

CCR5	Ccr5^−/− C	57BL/6J	141	31	0.968	0.891	0.992 (0.889–1.108)
CCR5	wt	C57BL/6J	145	82^‡	0.968	0.891	0.992 (0.889–1.108)

Mice were inoculated i.c. with RML prions.

^†

n, number of inoculated mice.

^‡§

Experiments were listed more than once for better comparison.