Table 5. Cell wall surface anchor family proteins in S. mitis B6 (LPXTG).
| S. mitis a | S. mitis | S. pneumoniae | homology/featuresb | |||
| smi (size, aa) | gene | NCTC 12261 | R6 gene (aa) | TIGR4 gene (aa) | ||
| 0091 (899) | 0 | + | spr0075 (1171) | SP0082 (857) | hypo, 152mer repeat (4) | |
| 0345 (1757) | 4 | + | spr0440 (1659) | SP0498 (1659) | hypo | |
| 0601 (1907) | nanA | 2 | − | spr1536 (1035) | SP1693 (962 stop) | sialidase A domain (neuraminidase A) |
| 0705 (2183) | prtA | 4 | − | spr0561 (2144) | SP0641 (2140) | cell wall-associated serine proteinase PrtA |
| 0810 (979) | 0 | − | − | − | hypo, coiled-coil domain; KA-rich 77mer repeats (6, deg.) | |
| 0979 (1218) | 1 | − | − | − | hypo, coiled-coil domain; KA-rich 77mer repeats (6) | |
| 1002 (4138) | 2 | (+) | − | − | hypo, Pro-rich; interspersed repetitive domains (95mers) | |
| 1064 (1702) | 2 | − | (−) | (−) | hypo, Pro-rich; interspersed repetitive domains (95mers) | |
| 1306 (2474) | 1 | (+) | − | − | hypo, coiled-coil domain; KA-rich 77mer repeats (8) | |
| 1317 (779) | 2 | (+) | − | − | hypo, Pro-rich; 36mer repeat (4) | |
| 1398 (1699) | 2 | − | − | − | serine protease | |
| 1482 (1969) | zmpB | 4 | + | spr0581 (1876) | SP0664 (1881) | zinc metalloprotease |
| 1531 (2997) | 6 | − | spr1403 (2551) | − | glycine rich protein (87mer repeat, 7) | |
| 1534 (2391) | bgaA | 0 | − | spr0565 (2228) | SP0648 (2233) | beta-galactosidase |
| 1537 (2770) | 0 | − | − | − | N-acetyl-beta-hexosaminidase | |
| 1538 (2322) | 0 | − | spr0328 (1767) | SP0368 (1767 fs) | hypo | |
| 1662 (1591)c | monX | 5 | − | − | SP1772 (4776) | hypo, Ser-rich repeats |
| 1848 (1298) | pulA | 9 | + | spr0247 (1256) | SP0268 (1280) | alkaline amylopullulanase |
aa: amino acids; + homologue present; - absent; (+) variable sequence; (−) fragments.
a
genomic hybridization with ten S. mitis strains using a S. mitis B6 specific microarray; the number refers to S. mitis strains giving positive signals.
b
hypo: hypothetical; the presence of large coiled-coil domains is indicated; the number in brackets refers to the number of repeats; deg.: degenerate.
c
the number corresponds to the sequenced region; the estimated size according to Southern hybridization is approximately 4,200 aa.