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. 2010 Feb 25;5(2):e9432. doi: 10.1371/journal.pone.0009432

Table 2. Overview of PspA peptide predicted binding affinities to MHC class II alleles.

PspA Peptide Number IC50 in silico prediction (nM)
I-Ab I-Ad I-Eb I-Ed HLA-DRB, -DP, -DQ Alleles with IC50<500 nM predicted peptide-binding affinity
01 312 177 – – 1*0101, 1*0301, 1*0401, 1*0404, 1*0405, 1*0701, 1*0802, 1*0901, 1*1101, 1*1302, 4*0101, 5*0101
02 316 81 – 372 1*0101, 1*0401, 1*0404, 1*0701, 1*1501,DP4, DPw4, DQ1, DQ5
03 171 21 358 – 1*0101, 1*0301, 1*0401, 1*0901, 1*0701, 5*0101
04 71 302 – – 1*0101, 1*0404, 1*0701, DP4, DP9
05 – – – – 1*0101, 1*0404, 1*0701, 1*0802, 5*0101, DQ5
06 167 56 – – 1*0101, 1*0404, 1*0701, DP9, DQ1, DQ5
07 338 – – – 1*0101, 1*0404, 1*0701, DQ8
08 118 17 – – 1*0101, 1*0404, 1*0701
09 219 57 499 – 1*0101, 1*0404, 1*0701, DP4, DPw4,
10 193 12 – 337 1*0101, 1*0404, 1*0701, 4*0101, DQ1, DQ2, DQ5, DQ7
11 223 215 – – 1*0101, 1*0401,1*0701, 1*0901, 3*0101, DQ8
12 380 488 – – 1*0101, 1*0301, 1*0701, 5*0101, DQ2
13 241 – 348 – 1*0101, 1*0401,1*0701, 1*0802, 5*0101, DP9, DPw4, DQ7, DQ8
14 210 34 – – 1*0101, 1*0401, 1*0701, 1*0405, 5*0101
15 354 46 – – 1*0101, 1*0401,1*0701, 1*0901, 5*0101, DP9 , DQ1, DQ2
16 182 99 – 344 1*0101, 1*0401,1*0701, DP9 , DQ7
17 49 – – – 1*0101, 1*0401,1*0701, DP9, DQ2
18 208 12 – 307 1*0101, 1*0401,1*0701, 1*0901, DQ8
19 205 104 – – 1*0101, 1*0401,1*0701, DQ2
20 485 – 493 – 1*0101, 1*0301,1*0401,1*0701, DP4, DP9, DPw4, DQ1
21 180 – – – 1*0101
22 121 42 – – 1*0101, 1*0401,1*0701,DP4, DP9, DQ1, DQ5
23 452 – 412 – 1*0101, 1*0401, 1*0405, 1*0701, 1*0802, 1*0901, 5*0101,DP4, DP9
24 374 – – – 1*0101, 1*0401,1*0701,
25 365 461 – – 1*0101, 1*0401,1*0701, DP9, DQ2
26 462 6 – – 1*0101, 1*0401,1*0405,1*0701, 5*0101, DQ2
27 249 112 – – 1*0101,1*0401, 1*0405, 1*0701, 1*0901, 5*0101,DP4, DP9, DQ5
28 124 190 – – 1*0101, 1*0401,1*0701, DP9, DQ7, DQ8
29 97 10 411 – 1*0101, 1*0401,1*0701, 1*0901, 5*0101, DQ5
30 99 125 – – 1*0101, 1*0401,1*0701, DQ2
31 173 57 – – 1*0101, 1*0401,1*0701, DQ2
32 350 15 – – 1*0101, 1*0401,1*0701, DQ2
33 239 – – – 1*0101, 1*0401,1*0701,
34 349 28 – – 1*0101, 1*0401,1*0701, DQ1
35 457 155 210 – 1*0101, 1*0401,1*0701, DPw4
36 211 65 – 479 1*0101, 1*0401,1*0701, DQ2
37 369 20 – 381 1*0101, 1*0401,1*0701,
38 140 105 – 378 1*0101, 1*0401, 1*0405, 1*0701, 1*1101, DQ1, DQ5, DQ7, DQ8
39 204 121 – 285 1*0401, 1*0405, 1*0701, 1*1302, 1*1501
40 348 76 381 – 1*0101, 1*0401, 1*0404, 1*0405, 1*0701, 1*0901, 1*1101, 1*1302, 1*1501, 5*0101,DP4, DPw4
41 264 60 268 – 1*0101,1*0401, 1*0404, 1*0405, 1*0701, 1*1302, 1*1501
42 256 175 – 357 1*0101, 1*0401, 1*0404, 1*0405, 1*0701, 1*0901, 1*1101, 1*1302, DQ8
43 329 21 – – 1*0101, 1*0401,1*0405, 1*0701, 1*1501, 3*0101, 5*0101
44 274 7 – – 1*0101, 1*0401, 1*0405, 1*0701, 1*1101, 1*1302, DQ7
45 485 60 – 476 1*0101, 1*0401, 1*0404, 1*0405, 1*0901, 1*1101, 3*0101, 5*0101
46 – 44 – – 1*0101, 1*0401, 1*0405, 1*0701, 1*1101
47 255 21 – – 1*0101, 1*0401, 1*0404, 1*0405, 1*0701, 1*0901, 1*1101, 1*1302, 3*0101, 5*0101
48 264 47 – – 1*0101,1*0401, 1*0404, 1*0405, 1*0701, 1*1302, 1*1501
49 255 120 – – 1*0101, 1*0401, 1*0404, 1*0405, 1*0701, 1*0901, 1*1101, 1*1302, 5*0101
50 329 – – – 1*0101, , 1*0401, 1*0405, 1*0701, 1*1501
51 255 45 – – 1*0101, 1*0401, 1*0404, 1*0405, 1*0701, 1*0901, 1*1101, 1*1302, 5*0101,DP4, DQ5
52 392 204 – – 1*0101, 1*0301,1*0401, 1*1501,1*0701
53 80 27 – – 1*0101, 1*0401, 1*0701, 1*0901, 5*0101,DP4, DPw4, DQ5
54 387 234 – 170 1*0101, 1*0401, 1*0701, 1*1501, 3*0101, DQ8

*Dashes (–) represent the predicted affinity of peptides that poorly (i.e., IC50>500 nM) bind mouse I-Ab, I-Eb, I-Ad, or I-Ed alleles. Similarly, absent HLA alleles are those that poorly (i.e., IC50>500 nM) bind the corresponding peptide.