Table 1. Summary of statistical comparisons.

Parameter	D+aCSF vs. NDa	D+aCSF vs. D+ins vs. D+ins+IGFb	D+ins+IGF vs. D+insc	ND vs. D+ins vs. D+ins+IGFd
Brain wet wt.	<0.013*	<0.025†	<0.018‡	<0.98
		<0.001†		<0.052
Brain dry wt.	<0.045*	<0.023†	<0.003‡	<0.99
		<0.001†		<0.002*
Brain water wt.	<0.010*	<0.030†	<0.037‡	<0.95
		<0.001†		<0.14
DNA	<0.029*	<0.78	<0.001‡	<0.20
		<0.001†		<0.001*
Total protein	<0.050*	<0.078	<0.61	<0.99
		<0.004†		<0.79
Actin	<0.003*	<0.850	<0.38	<0.021*
		<0.093		<0.44
α-tubulin	<0.001*	<0.49	<0.061	<0.009*
		<0.002†		<0.82
β-tubulin	<0.001*	<0.76	<0.15	<0.016*
		<0.017†		<0.71
GFAP	<0.001*	<0.008†	<0.024‡	<0.001*
		<0.001†		<0.15
GS	<0.14	<0.001†	<0.73	<0.20
		<0.011†		<0.70
PLP	<0.040*	<0.044†	<0.030‡	1
		<0.001†		<0.032*
MBP	<0.001*	<0.011†	<0.63	<0.64
		<0.001†		1
β-III tubulin	<0.001*	<0.24	<0.17	<0.003*
		<0.002†		<0.32
NF-L	<0.001*	<0.23	<0.18	<0.006*
		<0.002†		<0.42
NF-M	<0.001*	<0.80	<0.006‡	<0.001*
		<0.001†		<0.28

^aShows whether the parameter was significantly reduced in diabetes.

^bShows the effect of insulin alone or insulin's combination with IGF-I on the parameter in diabetes.

^cShows whether insulin's combination with IGF-I was more effective than insulin alone. Notice that combo treatment exceeded ND group in few cases.

^dShows whether the treatments normalized the parameter reduced in diabetes such that it no longer statistically differed from the non-diabetic group.

Significance accepted at p<0.05, Tukey-Kramer posthoc test of means.