Fig. 3.

a Dermal capillary (case 1) showing a level of degeneration approaching cytoplasmic lysis (asterisks). b Dermal capillary (case 2) showing endothelial-cell (EC) hypertrophy and numerous surrounding pericytes. Note that one of the pericytes (P) is some distance from the capillary and completely detached but still expresses a pericellular membrane and subplasmalemmal microvesicles around its entire perimeter. c Dermis (case 1) showing structures compatible with EC sprouting. There is a single EC (EC) with three cytoplasmic extensions, one of them definitely luminized (Lu). d Branched dermal capillary (case 1). Note the large lumen at the right lined with very thin EC cytoplasm. On the left are three enlarged ECs, which are prominently protruding into the obliterated lumen. The architectural pattern is compatible with intussusceptive-type angiogenesis