Table 2.

The composition of the myxoid ECM is heterogeneous but not lesion-specific

	Proteoglycans	Collagens (types)	Other ECM components	References
Non-neoplastic myxoid lesions
Follicular mucinosis	HA			[55]
Myxedema	HA	I (III)		[56, 57]
Stenotic arteries	Versican, biglycan, perlecan, HA	I	TBFbeta1	[58, 59]
Pseudoaneurysm	Versican			[60]
Endocardiosis	HA			[61]
Valvular degeneration of the heart		I, III		[62]
Myxoid tumors of soft tissue
Intramuscular myxoma	KS, HA, C4S, C6S	I, VI	Albumin, IgGs	[20, 34]
Myxofibrosarcoma	KS, HA, C4S, C6S	I, VI, XII, XIV	Thrombospondin Albumin, IgGs	[8, 20, 34]
Extraskeletal myxoid chondrosarcoma	C4S, C6S, HA (aggrecan)	I, III, VI (II, IV)	Albumin, IgGs	[20, 63]
Odontogenic myxoma	C4S, C6S, DS, KS, HS, aggrecan, versican, biglycan, decorin			[64]
Low-grade fibromyxoid sarcoma	HA			[65]
Myxoid neurothekeoma	HA			[66]
Myxoid lipoma (myxolipoma)	HA			[67]
Myxoid liposarcoma	HA		FN	[68]
Myxoid chondroma	HA, KS			[69]
Myxoid neurofibroma	HA, C4S, C6S			[69]
Chondromyxoid fibroma	Aggrecan	I, III, VI		[70]
Myxoid dermatofibroma	HA			[71]
Myxoid leiomyosarcoma	HA			[72]
Cardiac myxoma	C4S, C6S, (HA)			[73]
Ossifying fibromyxoid tumor		IV (II)		[74, 75]
Myxoinflammatory fibroblastic sarcoma			A1AT, A1ACT	[76]
Cutaneous myxoid cyst	HA			[77]
Aggressive angiomyxoma	HA			[78]
Cutaneous myxoma (superficial angiomyxoma)	HA			[79]
Myxoid areas in epithelial tumors
Breast carcinoma	Aggrecan, versican, HA	I, II, IV		[80]
Pleiomorphic adenoma	Lumican, perlecan, aggrecan, C4S, C6S, DS, KS, HA	I, III, IV	FGF2, Tenascin, FN, ChM-I	[81–83]
Vulvar squamous cell carcinoma			CD44, TGF-beta3	[84]
Mixed tumor of skin		IV	Tenascin, FN	[85]
Cholangiocarcinoma	Perlecan			[86]
Miscellaneous tumors (nonsoft tissue, nonepithelial)
Myxopapillary ependymoma	HA, CS, HS			[87]
Myxoid mesothelioma	HA			[88]
Myxoid meningioma	HA, CS			[89]

KS keratin sulfate, HA hyaluronic acid, C4S chondroitin sulfate, C6S chondroitin 6 sulfate, DS dermatan sulfate, HS heparan sulfate