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. 2009 Dec 22;59(3):588–599. doi: 10.2337/db09-0796

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© 2010 by the American Diabetes Association.

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FIG. 8. — Schematic representation of the mechanism by which inhibition of PTP1B promotes insulin sensitivity in the liver of IRS2-deficient mice. The lack of PTP1B promotes insulin sensitivity in the liver of IRS2^−/− mice through the restoration of IRS1-mediated Akt/Foxo1 phosphorylation (pAkt and pFoxo1) and the inhibition of gluconeogenic enzymes. This molecular mechanism can be mimicked by resveratrol through downregulation of PTP1B expression and activity in the liver of IRS2^−/− mice. PI 3-K, PI 3-kinase.