TABLE 2.

Individual effects of insulin and saline with bumetanide on cerebral metabolites during DKA: regression-adjusted main effects of each treatment

Metabolite	Adjusted main effect of insulin and saline	P	Adjusted main effect of bumetanide	P
ATP-to-Pi	−0.34 ± 0.13	0.02	0.38 ± 0.15	0.01
PCR-to-Pi	−0.29 ± 0.10	0.007	0.31 ± 0.13	0.03
NAA-to-Cr	−0.08 ± 0.03	0.020	−0.001 ± 0.03	0.97
Intracellular pH	0.13 ± 0.04	0.005	−0.002 ± 0.04	0.72

Data are means ± SE unless otherwise indicated. ATP-to-Pi and PCR-to-Pi ratios were analyzed as log-transformed values.