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. 2009 Dec 3;59(3):686–693. doi: 10.2337/db09-1291

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© 2010 by the American Diabetes Association.

Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.

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FIG. 5. — Treatment with CL-316243 reverses the accelerated growth of advanced Neu/ErbB2-induced mammary tumors. MCNeuA cells (10⁶) were orthotopically injected into the no. 4 mammary fat pad of 8-week-old virgin wild-type or MKR^+/+ mice. At 7 days after cell injection, treatment with either CL-316243 (CL) or vehicle (V) was initiated. A: Tumor growth was followed by measuring tumor volume weekly and was calculated as indicated in the research design and methods section. Arrow indicates the beginning of treatment. B: Wet tumor weight was determined at the end of the study. CL-316243, ■; vehicle, □. Data are expressed as means ± SEM. *P ≤ 0.05 for CL-316243 vs. vehicle group; #P ≤ 0.05 for wild-type vs. MKR^+/+ from the same treatment group. n = 7–8 mice/group.