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. 2010 Feb;184(2):393–400. doi: 10.1534/genetics.109.110213

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Copyright © 2010 by the Genetics Society of America

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Figure 3.— — Sensitivity of our inference to the effective population size, N_e. For N_e ∼ 5 × 10⁶, as estimated for Saccharomyces, we infer a role for natural selection in favoring [PSI+]-mediated evolvability if and only if m_PSI is elevated by stress, as has been observed. (a) For N_e ≲ 10⁵ we would not infer evolvability, even with realistically elevated switching rates. (b) Selection for evolvability would be inferred even in the absence of stress-mediated induction for N_e ≳ 4 × 10⁷. Higher values of N_e are not shown because their computation requires excessive memory, but the result is still clear.

Figure 3.— — Sensitivity of our inference to the effective population size, N_e. For N_e ∼ 5 × 10⁶, as estimated for Saccharomyces, we infer a role for natural selection in favoring [PSI+]-mediated evolvability if and only if m_PSI is elevated by stress, as has been observed. (a) For N_e ≲ 10⁵ we would not infer evolvability, even with realistically elevated switching rates. (b) Selection for evolvability would be inferred even in the absence of stress-mediated induction for N_e ≳ 4 × 10⁷. Higher values of N_e are not shown because their computation requires excessive memory, but the result is still clear.