Skip to main content
. 2010 Jan 15;11(2):97–105. doi: 10.1038/embor.2009.276

Figure 1.

Figure 1

TGF-β activation by integrins. (A) Protease-dependent activation by integrin αvβ8 and MMP14. (B) Protease-independent activation results from a conformational change of LAP–TGF-β induced by cell traction forces. FXa, coagulation factor X; Gαq, G protein αq; LAP, latency-associated protein; LPA, lysophosphatidic acid; LPAR2, lysophosphatidic acid receptor 2; LTBP, latent TGF-β binding protein; MMP14, matrix metalloproteinase 14; PAR1, protease-activated receptor 1; ROCK; Rho-associated kinase; TGF-β, transforming growth factor-β; TGF-βR, transforming growth factor-β receptor.