Table 1.
Fluorescence increases of the C-terminal Stargazin-derived peptide library with PSD-95 and Shank3 PDZ domains.
| Entry | Peptide Sequencea | Relative Fluorescence Increase | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| −9 | −5 | 0 | PSD95-3 | PSD95-12 | Shank3 | ||||||||
| 1 | AC-N | T | A | N | R | R | T | T | α | V-COOH | 1.9 | 2.5 | 1.0 |
| 2 | AC-N | T | A | N | R | R | α | T | P | V-COOH | 6.6 | 3.4 | 1.1 |
| 3 | AC-N | T | A | N | R | α | T | T | P | V-COOH | 1.7 | 1.5 | 1.0 |
| 4 | AC-N | T | A | N | R | β | T | T | P | V-COOH | 8.0 | 1.5 | 1.5 |
| 5 | AC-N | T | A | N | α | R | T | T | P | V-COOH | 36.1 | 1.8 | 2.0 |
| 6 | AC-N | T | A | N | β | R | T | T | P | V-COOH | 89.5 | 3.9 | 26.7 |
| 7 | AC-N | T | A | N | γ | R | T | T | P | V-COOH | 37.6 | 2.6 | 3.0 |
| 8 | AC-N | T | A | β | R | R | T | T | P | V-COOH | 19.8 | 1.9 | 1.2 |
| 9 | AC-N | T | β | N | R | R | T | T | P | V-COOH | 28.7 | 1.7 | 1.3 |
| 10 | AC-N | β | A | N | R | R | T | T | P | V-COOH | 25.6 | 1.9 | 1.3 |
| 11 | AC-β | T | A | N | R | R | T | T | P | V-COOH | 17.4 | 2.0 | 1.3 |
a
α = Dap(4-DMAP), β = Dab(4-DMAP), γ= Orn(4-DMAP).