Figure 6.

Prediction of 1 year cortical change from baseline CSF biomarker levels. One year change in cortical volume in MCI was predicted from baseline CSF biomarker values point by point across the cortical surface, with age and sex used as covariates. The top shows uncorrected p values, and the bottom shows the p maps thresholded at FDR < 0.05. Higher values of t-tau and lower values of Aβ₄₂ at baseline were associated with a larger percentage decrease in cortical volume over 1 year (red–yellow colors). The corrected p maps indicate that this effect is somewhat larger in the left hemisphere for Aβ₄₂. The uncorrected maps show that the right hemisphere has the same pattern of effects, but the p values were lower.