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. Author manuscript; available in PMC: 2010 Dec 1.
Published in final edited form as: Arthritis Rheum. 2009 Dec;60(12):3784–3793. doi: 10.1002/art.24977

Figure 2. CTX-treated muscle undergoes degeneration and subsequent repair.

Figure 2

Uninjured and CTX-injected tibialis anterior muscle specimens were obtained from mice sacrificed at days 2, 3, 5, and 12 following muscle injury. These samples were flash frozen, sectioned, stained with H&E, and visualized by light microscopy. The myofibers underwent extensive destruction followed by regeneration; with the exception of persistent internalization of myonuclei, muscle regeneration is virtually complete by day 12 after muscle injury.