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. 2010 Mar;135(3):261–274. doi: 10.1085/jgp.200910288

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© 2010 Bruhova and Zhorov

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

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Figure 3. — The extracellular views of various orientations of ^mCⁱ¹⁸ residues in Ca_v2.1. For clarity, the P loops are not shown. The red cross indicates the pore axis. (A) Cation–π interactions with Y²ⁱ¹⁶ stabilize the repeat interface orientation ^mC¹ⁱ¹⁸; the pore orientations have higher energy. (B) In the most preferable conformations, ^mC²ⁱ¹⁸ is oriented in the pore. (C) Cation–π interactions with F⁴ⁱ¹² and F³ⁱ²² stabilize orientation of ^mC³ⁱ¹⁸ in the repeat interface; the pore orientations are less preferable. (D) Both pore and repeat interface orientations of ^mC⁴ⁱ¹⁸ are energetically favorable.